Table 2.

Associations between chronotype and prevalent comorbidities adjusting for age and sex. Chronotype was examined as both an pseudo-continuous 4-level variable and as categorical variables with Definite Morning Type as Referent.

	4-level Chronotype	Categorical Variables
	(1= definite morning type to 4= definite evening type)	Definite Morning Type	Moderate Morning Types	Moderate Evening Types	Definite Evening Type
Prevalent Comorbidity	OR per level (95% CI)		OR (95% CI)	OR (95% CI)	OR (95% CI)
CVD	1.01 (1.004, 1.02) p=.002	Ref	0.91 (0.90, 0.93) p<.001	0.97 (0.95, 0.99) p=.001	1.07 (1.04, 1.10) p<.001
Diabetes	1.06 (1.05, 1.08) p<.001	Ref	0.82 (0.80, 0.85) p<.001	0.98 (0.94, 1.01) p=.20	1.30 (1.24, 1.36) p<.001
Neurological	1.06 (1.05, 1.08) p<.001	Ref	1.02 (1.00, 1.04) p=.20	1.08 (1.05, 1.11) p<.001	1.25 (1.20, 1.30) p<.001
Endocrine	1.04 (1.03, 1.06) p<.001	Ref	0.98 (0.95, 1.02) p=.34	1.04 (1.01, 1.08) p=.015	1.17 (1.12, 1.23) p<.001
Renal	1.02 (1.004, 1.04) p=.015	Ref	1.01 (0.97, 1.05) p=.65	1.01 (0.97, 1.05) p=.58	1.10 (1.04, 1.16) p=.001
Respiratory	1.05 (1.04, 1.06) p<.001	Ref	0.94 (0.92, 0.96) p<.001	1.03 (1.01, 1.05) p=.007	1.22 (1.18, 1.26) p<.001
Musculoskeletal	1.04 (1.03, 1.05) p<.001	Ref	0.96 (0.94, 0.98) p<.001	1.05 (1.03, 1.07) p<.001	1.14 (1.11, 1.18) p<.001
Gastrointestinal/abdominal	1.07 (1.06, 1.08) p<.001	Ref	1.00 (0.98, 1.02) p=1.0	1.12 (1.09, 1.14) p<.001	1.23 (1.19, 1.27) p<.001
Psychological	1.25 (1.23, 1.26) p<.001	Ref	1.07 (1.04, 1.11) p<.001	1.44 (1.40, 1.49) p<.001	1.94 (1.86, 2.02) p<.001