Table 1.

Immunoglobulin content in esophageal mucosal biopsy tissue^a

Immunoglobulin, median (IQR)	Control subjects	Subjects with EoE	EoE/Control ratio	P valueb
IgE	19.5 [18.8-20.4]	18.7 [18.2-19.1]	1.0	0.0620
IgA	0.9 [0.5-1.4]	2.0 [1.8-4.6]	2.2	< 0.0001
IgM	0.9 [0.6-1.5]	2.3 [0.9-3.9]	2.6	0.0102
IgG1	9.0 [6.6-10.2]	13.4 [9.5-18.4]	1.5	0.0132
IgG2	8.1 [2.7-11.2]	16.2 [9.7-32.6]	2.0	0.0122
IgG3	0.6 [0.5-1.0]	2.2 [1.3-5.1]	3.7	< 0.0001
IgG4	0.2 [0.1-0.9]	4.2 [1.0-13.1]	21.0	< 0.0001
IgG4, % total IgG	4.5% [1.8-9.3]	18.0% [6.5-23.5]	4.0	0.0122

^aIgE measurements are reported in micrograms immunoglobulin per gram of total protein. IgA, IgM, and IgG1-IgG4 measurements are reported in milligrams immunoglobulin per gram of total protein.

^bComparison of medians by Mann-Whitney U test.