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. Author manuscript; available in PMC: 2019 Feb 6.
Published in final edited form as: Nat Neurosci. 2018 Aug 6;21(9):1251–1259. doi: 10.1038/s41593-018-0195-0

Figure 7.

Figure 7

Expression profiles of genes which exhibit strong hierarchical gradients tend to be relatively stable across individuals. (a) Differential stability across cortex (DSC), defined as the mean pairwise Spearman rank correlation between subjects’ cortical gene expression maps, as a function of the magnitude of the T1w/T2w map correlation (TMC) for all 16088 genes (rs = 0.66, P < 10−5; Spearman rank correlation). Each gray dot represents a single gene. The black line indicates the average value in a sliding window of size 600 points. (b) Filtering genes by a threshold on DSC alters the shape of the TMC distribution. Increasing the DSC threshold filters out genes whose cortical expression profiles are not relatively consistent across subjects. The trough which develops near TMC=0 suggests that high-DSC genes preferentially exhibit strong hierarchical gradients. (c) Thresholding genes by DSC substantially increases variance captured by the first principal component (PC1) of gene expression variation (blue), whereas it has little effect on PC1’s TMC (red). Shaded regions in panels b and c mark the bootstrap estimated 95% confidence interval. Number of genes which exceed each DSC threshold: 0, 14509; 0.025, 12169; 0.05, 9494; 0.075, 7332; 0.1, 5853.