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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Neurobiol Aging. 2018 Jun 12;70:86–91. doi: 10.1016/j.neurobiolaging.2018.06.006

Figure 1. Impairment of LTP in mhAPP slices is prevented by MW150.

Figure 1

A) In 2-month old animals, LTP induction and maintenance was not affected by 14-day treatment with MW150 (2.5 mg/kg i.p.) in WT (open triangles) but rescued a normal LTP in slices from mhAPP mice (grey diamonds). Controls received 14-day i.p. injection of the vehicle (saline). B) Acute inhibition of p38MAPK by slices perfusion with either SB203580 (1μM) or MW150 (10μM) did not affect LTP in control WT (open circles and triangles) but was capable of rescuing a robust LTP in mhAPP slices with a comparable efficacy (light and dark grey diamonds). C) In vivo treatment with MW150 (2.5 mg/kg i.p.) confirmed its efficacy in 6-month old mhAPP mice. The mean LTP in the EC of mhAPP + MW150 mice (grey triangles) was comparable to controls (open circles and triangles) and significantly increased respect to mhAPP + vehicle group. Error bars indicate SEM