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. 2018 May 17;103(9):1462–1471. doi: 10.3324/haematol.2017.186734

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Figure 2. — RNA sequencing identified transforming growth factor β1 as the most probable secreted upstream regulator inducing the aberrant gene expression patterns. (A) Ingenuity pathway analysis²⁹ predicted that TNFα and TGFβ1 are the most probable secreted upstream regulators of the gene expression aberrations observed in the MSC from MDS and AML patients. (B) GSEA confirmed that overactivation of TGFβ1 signaling, but not TNFa, in the bone marrow caused the aberrant gene expression patterns. For both plots, the normalized enriched score (NES), false discovery rate (FDR) and P-values are given.