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. 2018 May 17;103(9):1493–1501. doi: 10.3324/haematol.2017.186700

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Figure 4. — xCT knockdown in mesenchymal stem cells (MSC) overcomes MSC mediated resistance to parthenolide (PTL). Viability of T-cell acute lymphoblastic leukemia (T-ALL) samples (patients 5, 6, 8-10) treated with 10 μM PTL for 24 hours (h) in the presence of MSC pre-treated with xCT or scramble control siRNA, in direct contact (A) or samples (1, 2, 6, 8, and 10) in transwell inserts (B). Symbols represent the average viability in duplicate samples. Each symbol represents an individual patient. Lines represent median and interquartile range. (C) Thiol concentration in media following 24-h incubation with MSC pre-treated with xCT or scramble control siRNA compared to background media. Data represent mean±Standard Deviation. (n=4). Results were analyzed by one-way ANOVA (A) or paired t-tests (B and C). *P≤0.05, **P≤0.01.