Table 3.
Differences in pooled mean costs and effects
| Analysis | N e-Exercise | N Usual PT | Outcome | ΔC (95% CI) In euro’s | ΔE (95% CI) In points | ICER Euro/point | Distribution CE-plane (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| NEa | SEb | SWc | NWd | |||||||
| Main analysis 1: | 109 | 99 | QALYs (0–1) | −529 (− 2265 to 1268) | 0.01 (− 0.03 to 0.04) | −52,900 | 17.8 | 42.1 | 23.2 | 16.9 |
| Total costs and imputed dataset | 109 | 99 | Physical functioning (0–100) | −529 (−2265 to 1268) | 1.49 (−4.70 to 7.69) | −355 | 20.5 | 44.7 | 20.6 | 14.2 |
| 109 | 99 | Physical activity (min/day) | −529 (−2265 to 1268) | −3.46 (−11.66 to 4.73) | 153 | 7.7 | 9.4 | 55.9 | 27.0 | |
| Main analysis 2: | 109 | 99 | QALYs (0–1) | −792 (− 2101 to 440) | 0.01 (−0.03 to 0.04) | −79,200 | 13.5 | 46.4 | 33.4 | 6.7 |
| Healthcare costs and imputed dataset | 109 | 99 | Physical functioning (0–100) | −792 (−2101 to 440) | 1.49 (−4.70 to 7.69) | −532 | 14.4 | 50.7 | 29.2 | 5.7 |
| 109 | 99 | Physical activity (min/day) | −792 (−2101 to 440) | −3.46 (−11.66 to 4.73) | 229 | 5.2 | 11.9 | 67.9 | 15.0 | |
| Sensitivity analysis 1: | 42 | 36 | QALYs (0–1) | 2211 (701 to 3722) | −0.00 (−0.03 to 0.03) | −22,110 | 34.8 | 0.1 | 0.1 | 65.0 |
| Complete cases | 42 | 36 | Physical functioning (0–100) | 2211 (701 to 3722) | −2.15 (−7.50 to 3.20) | −1.028 | 18.4 | 0.0 | 0.2 | 81.4 |
| 42 | 36 | Physical activity (min/day) | 2211 (701 to 3722) | −1.95 (−7.43 to 3.53) | − 1.134 | 22.0 | 0.0 | 0.2 | 77.8 | |
| Sensitivity analysis 2: | 39 | 99 | QALYs (0–1) | − 592 (− 2719 to 1603) | 0.02 (−0.01 to 0.06) | − 29,600 | 29.0 | 65.6 | 1.4 | 4.0 |
| Per-protocol and imputed dataset | 39 | 99 | Physical functioning (0–100) | −592 (−2719 to 1603) | 4.10 (−1.56 to 9.77) | − 144 | 30.7 | 66.1 | 0.8 | 2.4 |
| 39 | 99 | Physical activity (min/day) | −592 (−2719 to 1603) | −1.79 (− 8.72 to 5.13) | 331 | 12.8 | 18.3 | 48.7 | 20.2 | |
CI confidence interval, C costs, CE-plane cost-effectiveness plane, E effects, ICER incremental cost-effectiveness Ratio costs are expressed in 2015 Euros
aThe northeast quadrant of the CE plane, indicating that e-Exercise is more effective and more costly than usual physiotherapy
bThe southeast quadrant of the CE plane, indicating that e-Exercise is more effective and less costly than usual physiotherapy
cThe northwest quadrant of the CE plane, indicating that e-Exercise is less effective and more costly than usual physiotherapy
dThe southwest quadrant of the CE plane, indicating that e-Exercise is less effective and less costly than usual physiotherapy