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. 2018 May 31;21(9):822–827. doi: 10.1093/ijnp/pyy050

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Functional analysis of MAOA promoter/exon I/intron I DNA methylation using luciferase-based reporter gene assays. Left: Normalized reporter gene activity was significantly decreased in the presence of pCpGfree-promoter Lucia_MAOA vectors containing the methylated insert spanning CpGs 1–13 compared with those carrying a nonmethylated insert; ***P < .001. Right: No significant difference in normalized reporter gene activity was discerned between methylated or non-methylated pCpGfree-promoter Lucia control vectors lacking the insert of the sequence spanning CpGs 1–13.