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. 2018 Apr 23;21(9):858–870. doi: 10.1093/ijnp/pyy040

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Effects of corticosterone (CORT) treatment on behavior tests and Dkk-1 expression in rats. (A–B) Effects of CORT treatment on sucrose preference and immobility time in forced swimming test. (C) Effects of CORT treatment on escape latency during training days 2 to 4 in the acquisition trials of Morris water maze test. (D–E) In the probe trial, rats treated with chronic CORT showed fewer crossing times over the platform position and less time spent in the target quadrant. (F) Effects of CORT treatment and CUS on plasma corticosterone levels. (G) Western-blotting analysis showing the effects of CORT treatments on hippocampal total GSK-3β, phospho-Ser9-GSK-3β, and Dkk-1 expression. (H) Quantification of western-blotting signals of total GSK-3β, phospho-Ser9-GSK-3β, Dkk-1, and α-tubulin proteins. Data are presented as mean±SEM (n=6/group). *P<.05, **P<.01 vs control group.