Table 3.

Changes in CGM glycaemic indices from baseline between low dose or high dose BTI320 and placebo using random effect models with repeated measurements adjusted for intra-individual between-meal and between meal-day variability

CGM Parameter	Low Dose BTI320		High Dose BTI320
	Mean Difference (95% CI)	p	Mean Difference (95% CI)	p
AUCpp at 1 h	−0.30 (− 0.48, − 0.11)	< 0.01	−0.14 (− 0.32, 0.04)	0.13
AUCpp at 2 h	−0.59 (− 1.01, − 0.18)	0.01	−0.17 (− 0.57, 0.24)	0.42
AUCpp at 3 h	−0.74 (− 1.35, − 0.14)	0.02	−0.17 (− 0.75, 0.42)	0.57
MPMG	−0.42 (− 0.81, − 0.03)	0.03	−0.09 (− 0.48, 0.29)	0.63
SD at 1 h	−0.05 (− 0.13, 0.02)	0.18	0.01 (− 0.06, 0.09)	0.73
SD at 2 h	−0.07 (− 0.15, 0.00)	0.06	0.03 (− 0.05, 0.10)	0.46
SD at 3 h	−0.07 (− 0.15, 0.00)	0.06	0.03 (− 0.05, 0.10)	0.46
% CV at 1 h	−0.48 (− 1.46, 0.50)	0.34	0.22 (− 0.73, 1.18)	0.64
% CV at 2 h	−0.62 (− 1.50, 0.26)	0.17	0.39 (− 0.46, 1.24)	0.37
% CV at 3 h	−0.65 (− 1.62, 0.31)	0.18	0.42 (− 0.51, 1.36)	0.37

AUCpp post-prandial incremental area-under-curve, CGM Continuous Glucose monitoring, CI Confidence interval, CV coefficient of variation, MPMG mean post-meal maximum glucose, SD standard deviation