Table 4.

Adverse reactions

Adverse reactiona	Osurnia		Placebo
	N	% of total (n = 190)	N	% of total (n = 158)
Elevated Alkaline Phosphatase	15	7.9	3	3.2
Vomiting	7	3.7	1	1.1
Elevated AST, ALT, ALPa	2	1.1	0	0.0
Weight Loss (10% BW)	1	0.53	0	0.0
Hearing Decrease/Loss	1	0.53	1	1.1

^aAspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP). Two dogs with pre-existing elevations in ALP were reported to have an increase in liver enzymes (ALP, ALT and/or AST) at study exit. Subsequent clinical chemistries returned to normal