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Subgroup analyses: Kappa values
| Subgroup | Number (%) | Kappa value (95% CI) |
| Small molecule drugs | 286 | 0.313 (0.205 to 0.420) |
| Biologics | 99 | 0.233 (0.061 to 0.405) |
| Antineoplastic agents | 71 | 0.091 (0.017 to 0.200) |
| Antivirals for systemic use | 46 | 0.122 (0.011 to 0.233) |
| Immunosuppressants | 35 | 0.376 (0.075 to 0.675) |
| All other therapeutic groups | 357 | 0.385 (0.263 to 0.506) |
