Table 1. Diffusion and BBB Regression Results.

Linear regression analyses for acute and chronic diffusion metrics with acute and chronic BBB scores show significance for many diffusion metrics as well as changing sensitivities over time. All data were also analyzed without sham animals to determine significance of effect within the injury groups.

Metric		Acute MRI with Acute BBB Score		Chronic MRI with Chronic BBB Score		Acute MRI with Chronic BBB Score
		With Sham	Without Sham	With Sham	Without Sham	With Sham	Without Sham
FP-DDE	ADC||	R2 = 0.56 p < 0.0001	R2 = 0.03 p = 0.30	R2 = 0.29 p < 0.0001	R2 = 0.02 p = 0.45	R2 = 0.63 p < 0.0001	R2 = 0.31 p = 0.0003
	fR	R2 = 0.46 p < 0.0001	R2 = 0.05 p = 0.17	R2 = 0.14 p = 0.008	R2 = 0.00 p = 0.71	R2 = 0.55 p < 0.0001	R2 = 0.26 p = 0.0009
DTI	FA	R2 = 0.54 p < 0.0001	R2 = 0.03 p = 0.33	R2 = 0.46 p < 0.0001	R2 = 0.02 p = 0.36	R2 = 0.52 p < 0.0001	R2 = 0.12 p = 0.03
	AD	R2 = 0.37 p < 0.0001	R2 = 0.00 p = 0.70	R2 = 0.27 p = 0.0001	R2 = 0.10 p = 0.06	R2 = 0.52 p < 0.0001	R2 = 0.29 p = 0.0004
	RD	R2 = 0.05 p = 0.13	R2 = 0.00 p = 0.80	R2 = 0.20 p = 0.001	R2 = 0.04 p = 0.22	R2 = 0.00 p = 0.87	R2 = 0.11 p = 0.04
	MD	R2 = 0.12 p = 0.012	R2 = 0.00 p = 0.93	R2 = 0.01 p = 0.56	R2 = 0.08 p = 0.09	R2 = 0.29 p < 0.0001	R2 = 0.22 p = 0.002
WMTI	AWF	R2 = 0.05 p = 0.12	R2 = 0.00 p = 0.74	R2 = 0.23 p = 0.001	R2 = 0.00 p = 0.86	R2 = 0.00 p = 0.89	R2 = 0.08 p = 0.09
	Da	R2 = 0.52 p < 0.0001	R2 = 0.02 p = 0.42	R2 = 0.35 p < 0.0001	R2 = 0.00 p = 0.84	R2 = 0.56 p < 0.0001	R2 = 0.21 p = 0.003
	Depar	R2 = 0.47 p < 0.0001	R2 = 0.01 p = 0.59	R2 = 0.33 p < 0.0001	R2 = 0.08 p = 0.09	R2 = 0.55 p < 0.0001	R2 = 0.25 p = 0.001
	Deperp	R2 = 0.00 p = 0.86	R2 = 0.00 p = 0.91	R2 = 0.19 p = 0.002	R2 = 0.02 p = 0.41	R2 = 0.04 p = 0.18	R2 = 0.13 p = 0.03