Table 2. Histology Multiple Linear Regression.
Results of the multiple linear regression (Mult. Reg.) analysis of chronic histological staining with acute and chronic diffusion metrics and BBB scores. Standardized β coefficients are reported for each histological stain variable with significance of each indicated as *p<0.05, **p<0.01, ***p<0.005.
| Mult. Reg. | SMI31 | SMI32 | ED1 | DAPI | GFAP | ||
|---|---|---|---|---|---|---|---|
| Acute Diffusion | |||||||
| FP-DDE | ADC|| | R2 = 0.68 p < 0.0001 |
β = 0.21 | β = −0.65*** | β = −0.21 | β = 0.11 | β = 0.07 |
| fR | R2 = 0.55 p = 0.0001 |
β = −0.24 | β = 0.57** | β = 0.25 | β = −0.25 | β = −0.14 | |
| DTI | FA | R2 = 0.71 p < 0.0001 |
β = −0.07 | β = −0.26 | β = −0.40* | β = −0.34* | β = 0.07 |
| AD | R2 = 0.59 p < 0.0001 |
β = 0.17 | β = −0.30 | β = −0.32 | β = −0.16 | β = 0.25* | |
| RD | R2 = 0.16 p = 0.34 |
β = 0.24 | β = −0.13 | β = 0.17 | β = 0.10 | β = 0.24 | |
| MD | R2 = 0.35 p = 0.015 |
β = 0.23 | β = −0.27 | β = −0.15 | β = −0.07 | β = 0.29 | |
| WMTI | AWF | R2 = 0.13 p = 0.47 |
β = −0.17 | β = −0.08 | β = 0.11 | β = −0.15 | β = −0.25 |
| Da | R2 = 0.68 p < 0.0001 |
β = 0.09 | β = −0.20 | β = −0.31 | β = −0.42*** | β =0.10 | |
| DEpar | R2 = 0.68 p < 0.0001 |
β = 0.13 | β = −0.14 | β = −0.45** | β = −0.32* | β = 0.14 | |
| DEperp | R2 = 0.14 p = 0.45 |
β = 0.20 | β = −0.06 | β = 0.00 | β = −0.01 | β = 0.27 | |
| Chronic Diffusion | |||||||
| FP-DDE | ADC|| | R2 = 0.51 p = 0.0003 |
β = 0.20 | β = −0.36 | β = −0.07 | β = −0.28 | β = 0.08 |
| fR | R2 = 0.37 p = 0.012 |
β = −0.25 | β = 0.24 | β = −0.10 | β = 0.37 | β = −0.03 | |
| DTI | FA | R2 = 0.69 p < 0.0001 |
β = 0.11 | β = −0.70*** | β = −0.17 | β = 0.08 | β = −0.08 |
| AD | R2 = 0.41 p = 0.004 |
β = 0.19 | β = −0.60* | β = −0.13 | β = −0.08 | β = 0.07 | |
| RD | R2 = 0.47 p = 0.001 |
β = −0.02 | β = 0.51* | β = 0.27 | β = −0.18 | β = 0.16 | |
| MD | R2 = 0.15 p = 0.39 |
β = 0.09 | β = 0.08 | β = 0.31 | β = −0.21 | β = 0.18 | |
| WMTI | AWF | R2 = 0.41 p = 0.004 |
β = −0.04 | β = −0.45 | β = −0.30 | β = 0.18 | β = −0.13 |
| Da | R2 = 0.59 p < 0.0001 |
β = 0.02 | β = −0.70*** | β = −0.15 | β = 0.11 | β = −0.03 | |
| DEpar | R2 = 0.45 p = 0.002 |
β = 0.11 | β = −0.56* | β = −0.13 | β = 0.03 | β = 0.06 | |
| DEperp | R2 = 0.39 p = 0.008 |
β = −0.06 | β = 0.33 | β = 0.36 | β = −0.16 | β = 0.17 | |
| BBB Scoring | |||||||
| Acute | R2 = 0.72 p < 0.0001 |
β = 0.20 | β = −0.69*** | β = −0.07 | β = −0.06 | β = 0.00 | |
| Chronic | R2 = 0.63 p < 0.0001 |
β = 0.18 | β = −0.67*** | β = −0.05 | β = 0.03 | β = 0.19 | |