Table 1.
Effects of DOI, 25C-NBOMe, 25I-NBOMe, 2C-C and 2C-I on 5-HT2A receptor binding, calcium mobilization mediated by 5-HT2A and 5-HT2C receptors, and behaviors.
| Compound | 5-HT2A Inhibition of Binding IC50 (nM) |
5-HT2A Mobilization of Calcium++ EC50 (nM) [%Emax] |
5-HT2C Mobilization of Calcium++ EC50 (nM) [% Emax] |
Rat WDS ED50 (mg/kg, sc) |
Rat BMC ED50 (mg/kg, sc) |
|---|---|---|---|---|---|
| DOI | 56.1 ± 4.9 | 1.83 ± 0.3 [109] | 47.7 ± 3.0 [50] | 0.065 ± 0.024 | 0.180 ± 0.066 |
| 25C-NBOMe | 8.7 ± 1.0 | 61.7 ± 3.5 [104] | 178 ± 25 [60] | 0.010 ± 0.005 | 0.021 ± 0.008 |
| 25I-NBOMe | 3.9 ± 0.4 | 34.7 ± 4.2 [108] | 88.9 ± 11 [70] | 0.062 ± 0.026 | 0.037 ± 0.011 |
| 2C-C | 307.5 ± 21.6 | 4.57 ± 0.5 [95] | 77.6 ± 5.5 [29] | 0.173 ± 0.066 | 0.550 ± 0.190 |
| 2C-I | 124.9 ± 13.0 | 3.97 ± 0.7 [89] | 47.2 ± 6.7 [28] | 0.690 ± 0.268 | 0.192 ± 0.060 |