Table 3. Association between rs33912345 genotype and optic nerve head parameters.
Results are from multivariable linear regression models with the optic nerve head parameter as the dependent variable and genotype dosage as an explanatory variable. Parameters additionally adjusted for are indicated in the table. P-values < 0.008 (Bonferroni-corrected significance threshold for 6 tests) are in bold.
| Model 1 (adjusted for age, sex and disc area) |
Model 2 (adjusted for age, sex, disc area, axial length and IOPg) |
|||||
|---|---|---|---|---|---|---|
| Change per risk allele (C) | 95% CI | P-value | Change per risk allele (C) | 95% CI | P-value | |
| HRT rim area (mm2) | -0.030 | (-0.039, -0.020) | 2.56E-09 | -0.030 | (-0.040, -0.020) | 5.36E-09 |
| HRT VCDR | 0.025 | (0.017, 0.032) | 4.33E-10 | 0.025 | (0.017, 0.033) | 3.27E-10 |
| GDx RNFL thickness (μm) | -0.406 | (-0.637, -0.176) | 0.001 | -0.386 | (-0.624, -0.149) | 0.001 |