Table 4. Association between rs33912345 genotype and optic nerve head parameters stratified by age tertile.

Results are from multivariable linear regression models with the optic nerve head parameter as the dependent variable and genotype dosage as an explanatory variable, adjusted for sex, disc area, axial length and IOPg. P-values < 0.006 (Bonferroni-corrected significance threshold for 9 tests) are in bold.

	Lowest age tertile			Middle age tertile			Oldest age tertile
	Difference per risk allele	95% CI	P-value	Difference per risk allele	95% CI	P-value	Difference per risk allele	95% CI	P-value
HRT measures		n = 1811			n = 1811			n = 1811
Age range		48.49 - 63.79			63.80 - 70.96			70.97 - 89.65
HRT rim area (mm2)	-0.045	(-0.062, -0.029)	<0.001	-0.019	(-0.036, -0.003)	0.023	-0.024	(-0.043, -0.005)	0.013
HRT VCDR	0.032	(0.020, 0.045)	<0.001	0.017	(0.003, 0.030)	0.014	0.027	(0.012, 0.041)	<0.001
GDx measures		n = 1233			n = 1232			n = 1234
Age range (years)		48.49 - 63.19			63.20 - 69.54			69.55 - 88.26
GDx average thickness (μm)	-0.077	(-0.499, 0.345)	0.72	-0.379	(-0.778, 0.020)	0.06	-0.688	(-1.102, -0.274)	0.001