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Effects of age on epidermal nerve fiber density. Confocal images of glabrous skin biopsies taken from 2, 7, 18 and 24–26 months old control rats. The number of epidermal nerves in the image from the 7 months old animal is relatively higher than that from the other groups. The skin samples from the 24–26 month old rats displayed the most pronounced reduction of in epidermal innervation. Each image captured 634 μm of skin samples.
