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. Author manuscript; available in PMC: 2019 May 17.
Published in final edited form as: Cell. 2018 May 17;173(5):1123–1134.e11. doi: 10.1016/j.cell.2018.04.037

Figure 3. NKT Cells Are Required for Colonic Inflammation Induced by Frag-oz.

Figure 3

(A) Quantitative scoring for colitis after intra-rectal administration of 1% TMO or EtOH (50% v/v) vehicle in WT or CD1d-deficient (KO) littermates (n = 8). **p < 0.01 (Student’s t test).

(B) Quantification of IL-13 and IFN-γ production in overnatant of colon explants 2 days after intra-rectal administration of 1% TMO or EtOH (50% v/v) vehicle (n = 6). **p < 0.01 (Student’s t test).

(C) Weight change after intra-rectal administration of 1% Frag-oz or EtOH (50% v/v) vehicle in GF or SPF animals (n = 8). **p < 0.01, ***p < 0.001 (Mann-Whitney U test).

(D and E) Quantification of (D) Mttp and (E) Cyp1a1 transcripts (normalized to β-actin) from mucosal scraping 2 days after intra-rectal administration of 1% Frag-oz or EtOH (50% v/v) vehicle (n = 4). **p < 0.01, (Student’s t test)

(F) Quantitative scoring for colitis after intra-rectal administration of 1% TMO or EtOH (50% v/v) vehicle in GF or SPF animals (n = 8–9). **p < 0.01, p < 0.001 (Student’s t test).

See also Figure S3.