Figure 2.

Genes involved in regulating T cell/B cell collaboration are associated with autoimmunity. Manhattan plot of GWAS analysis for 10 selected autoimmune diseases: alopecia areata, autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease), celiac disease, juvenile idiopathic arthritis, MS, primary biliary cirrhosis, RA, SLE, T1D, and vitiligo. Statistical strength of association (-Log₁₀P) is plotted against genomic position. Single nucleotide polymorphisms (SNPs) in genes with known function in regulating T cell/B cell collaboration are marked with colored circles; other SNPs are marked with gray dots. More than 60% of the highlighted genes are implicated in more than one of the 10 selected autoimmune diseases. The NHGRI-EBI Catalog of published genome-wide association studies (98) was used to generate this figure (catalog version: gwas_catalog_v1.0.2-associations_e92_r2018-05-12; access date 17.05.2018). Only SNP traits with a p-value of <1.0 × 10⁻⁵ in the overall (initial GWAS + replication) population are included in this catalog. For clarity, the y-axis scale used in this figure excludes HLA-DRB1 SNP associations with -Log₁₀P values of 299, 250 (x2), 185.4 in RA and 224.4, 206, 183 in MS, and an insulin SNP association with -Log₁₀P of 185 in T1D. This figure only serves illustrative purposes and no direct comparisons should be made between associations taken from different studies.