Table 1.

| Suppression of congophilic amyloid plaque formation in the brain of B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J transgenic mice by intravenous injections of isoD7-pS8-Aβ42.

Transgenic mice (females)				Injection	Brain sections	Number of congophilic amyloid plaques per section	Statistical significance
Group name	Number of animals	Age at first injection (months)	Age at sacrifice (months)	Administered compound/total number of injections	Total number	In regions CA1, CA2, CA3, and the dentate gyrus of the hippocampus (mean ± SEM)	vs. Control
Control	4	-	8	PS (125 μl)/6	40	28.7 ± 4.6	-
IsoD7-pS8-Aβ42	7	2	8	Synthetic isoD7-pS8-Aβ42 (10 μg in 125 μl of PS)/6	70	7.4 ± 2.8	p < 0.001