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. 2018 Aug;188(8):1910–1920. doi: 10.1016/j.ajpath.2018.05.003

Figure 1.

Figure 1

Protein level and prognostic value of β-catenin and E-cadherin across 19 cancer types. A: Z-score protein level of β-catenin and E-cadherin in The Cancer Genome Atlas Pan-Cancer cohort (P < 0.001 for β-catenin and E-cadherin). B: Summary of Cox proportional hazard regression comparing the upper quartile with the lowest quartile of β-catenin protein level. Dotted line indicates P = 0.05. C: Summary of Cox proportional hazard regression comparing the upper quartile with the lowest quartile of E-cadherin protein level. Dotted line indicates P = 0.05. Size of points is on a relative scale on the basis of –log10(P value). n = 46 [A, adrenocortical carcinoma (ACC)]; n = 127 [A, bladder urothelial carcinoma (BLCA)]; n = 820 [A–C, breast invasive carcinoma (BRCA)]; n = 326 [A, colon adenocarcinoma (COAD)]; n = 201 [A and B, glioblastoma multiforme (GBM)]; n = 203 (A and B, head and neck squamous cell carcinoma (HNSC)]; n = 444 [A–C, kidney clear cell carcinoma (KIRC)]; n = 207 [A, kidney papillary cell carcinoma (KIRP) and skin cutaneous melanoma (SKCM), and C, KIRP]; n = 257 [A, lower-grade glioma (LGG)]; n = 233 [A, lung adenocarcinoma (LUAD)]; n = 192 [A, lung squamous cell carcinoma (LUSC)]; n = 408 [A, ovarian serous cystadenocarcinoma (OV)]; n = 105 [A, pancreatic adenocarcinoma (PAAD)]; n = 164 [A, prostate adenocarcinoma (PRAD)]; n = 127 [A, rectum adenocarcinoma (READ)]; n = 299 [A, stomach adenocarcinoma (STAD)]; n = 374 [A, thyroid carcinoma (THCA)]; n = 404 [A and C, uterine corpus endometrial carcinoma (UCEC)].