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. 2018 Aug;188(8):1910–1920. doi: 10.1016/j.ajpath.2018.05.003

Figure 4.

Figure 4

β-Catenin and E-cadherin protein in infiltrating ductal carcinoma (IDC) samples on the basis of immunohistochemical designation. Outliers, defined as E-cadherin <−3 and β-catenin >−3, circled withdotted line. A: Scatterplot of β-catenin and E-cadherin protein across IDC samples. B: Density histogram of mean-centralized quotient of β-catenin and E-cadherin. Cutoff values of −0.65 (low, left-bound dotted line) and 0.8 (high, right-bound dotted line) were used on the basis of distinct subpopulations. χ2 Tests were performed comparing low, high, and unaffected population distributions. C: Kaplan-Meier curve from the estrogen receptor (ER)+ (blue), human epidermal growth factor receptor 2 (HER2)+ (green), and triple-negative breast cancer (TNBC; red) samples in the METABRIC cohort using CDH1 levels split by auto-cutoff for high versus low samples, using Cox proportional hazard regression. NA, not applicable.