FIGURE 8.

Enriched metabolic receptors in monoaminergic brain regions. (A) Depicted metabolic receptor genes were among the top 1,000 genes (Figure 7C) that are highly coexpressed with monoamine markers Slc6a3 (in midbrain), Slc6a4 (in midbrain), and Dbh (in pons and medulla). These monoamine markers are expressed in monoamine producing nuclei, i.e., Slc6a3 in the ventral tegmental area (VTA) and the substantia nigra (SN), Slc6a4 in the raphe nuclei of the midbrain (RN) and Dbh in the nucleus parabrachialis (PB), the locus coeruleus (LC), and the nucleus tractus solitarii (NTS). Color code indicates the findings of our literature review. Red: the metabolic factor of the receptor was found to causally alter fear at the location as indicated in the figure. Blue: the metabolic factor of the receptor was found to causally alter fear, but the site of action was unknown. Green: the metabolic factor of the receptor was not found to causally alter fear. (B) Absolute expression summary of all enriched metabolic receptors in monoaminergic brain regions.