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. 2018 Aug 1;8(8):180052. doi: 10.1098/rsob.180052

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© 2018 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 7. — (a) The PIE-1 protein and germline specification in C. elegans embryos. PIE-1 protein is concentrated on centrosomes at both spindle poles and is further degradated asymmetrically after rotation by 90° of the posterior mitotic spindle (top row on the bottom left frame). After mitosis, PIE-1 maintains totipotency in the posterior blastomere (right frame) by repressing the somatic state (adapted from Mello et al. [272]). (b) Asymmetrical transport of germ plasm (Vasa in red) on astral microtubules (green) towards one spindle pole (left) directs germ cell development in Drosophila (right) (adapted from Lerit & Gavis [273]).