Figure 4.

Representative imaging from a tongue squamous cell carcinoma patient who achieved a favorable clinical response after CRT failure, a male initially treated with partial glossectomy and neck dissection and adjuvant CRT. (A–C) The tumor recurred in the trapezius (yellow ellipse), mediastinal lymph nodes, and lung (yellow arrowheads) 5 months after completion of CRT. (D–F) After four cycles of therapy (PTX 80 mg/m², days 1, 8, and 15; and Cmab, 400 mg/m² followed by a weekly 250 mg/m²; 28-day cycle), almost all recurrent lesions had disappeared and occipital pain was completely alleviated.