Figure 2.

Neuropathology from Patient 4. (A) The medial aspect of right cerebral hemisphere showing a thin corpus callosom with absent rostrum. (B) Midline sagittal section of brain stem and cerebellum showing mild hypoplasia of the cerebellar vermis. (C) Coronal section of the cerebral hemispheres. The corpus callosum is thinned and there is thickening of the cortex around the sylvian fissures. (D) Stained section of the right cerebral hemisphere revealing abnormal folding of the cortical ribbon around the sylvian fissure. (E) A magnified view of (D) demonstrating polymicrogyria around the sylvian fissure.