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(A) Number of entries in exposed arms (EOA); (B) Total amount of time spent in exposed arms (TOA); and (C) Total number of arms entries (TEA) in elevated plus maze in female and male rats after 2 month of treatment with 0.9% of NaCl (Control), 0.25 mg/kg (Ni-0.25), 0.5 mg/kg (Ni-0.5), and 1 mg/Kg (Ni-1) of Ni. Results are expressed as mean ± SEM. The significance level is 0.05. * p < 0.05, ** p < 0.01, *** p < 0.001.
