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. 2018 Sep 3;38:15. doi: 10.1186/s41232-018-0072-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Expression of M cell marker molecules during differentiation. a Fluorescence in situ hybridization (FISH) image of Spib, M-Sec, and Gp2 in a mouse FAE specimen is shown. Premature and immature M cells are observed at the crypt and the periphery of dome region, respectively, whereas fully mature M cells are found at the middle and upper dome region. b Enlarged images of the cypt region are shown. c RANKL from stromal M cell inducer (MCi) cells stimulates intestinal stem cells to initiate M cell differentiation. Early (Marksl1, AnnexinV), intermediate (Spi-B, Tnfaip2, CCL9), and mature (GP2) markers are serially expressed during the course of differentiation