Table 1.
Overview of the main features of some of the most prescribed topical anti-glaucoma medications available in the market.
| Generic Name* | % IOP Reduction from Baseline |
Year of
Introduction |
Instillation
Frequency |
Preservative Free | Wash-out Time | |
|---|---|---|---|---|---|---|
| Peak | Trough | |||||
| Pilocarpine | 25 | 20 | 1875 | 3-4 times daily | No | 1 week |
| Timolol | 27 | 26 | 1978 | 1-2 times daily | Yes/ No | 2-5 weeks |
| Dorzolamide | 20 | 17 | 1994 | 2-3 times daily | Yes | 1 week |
| Brimonidine | 25 | 18 | 1996 | 2-3 times daily | No | 1-3 weeks |
| Latanoprost | 31 | 28 | 1996 | Once daily | No/ Yes | 4-6 weeks |
| Brinzolamide | 20 | 17 | 1998 | 2-3 times daily | No | 1 week |
| Unoprostone | 20 | 15 | 2000 | 2 times daily | No | 4-6 weeks |
| Travoprost | 31 | 29 | 2001 | Once daily | No ** | 4-6 weeks |
| Bimatoprost (+) | 33 | 28 | 2001 | Once daily | No/ Yes | 4-6 weeks |
| Tafluprost | 27 | 20 | 2008 | Once daily | Yes | 4-6 weeks |