Table 5.
Animal models on the effects of antioxidants, essential fatty acids and natural compounds in glaucoma.
| Study (Assayed Substance) | Animal Model | References |
|---|---|---|
| Antioxidants: Vit E | Rat | Ku et al. 2010 [108] |
| Antioxidants: Vit E | Mouse | Hsu et al. 2015 [109] |
| Antioxidants: Vit C | Pig | Xu et al., 2014 [111] |
| Antioxidants: Resveratrol, Urate, Ascorbate, GSH, P-Coumarate | Pig | Amman et al,. 2012 [112] |
| Antioxidants: Co Q-10 | Rat |
Nucci et al., 2007 [113] Russo et al., 2008 [114] Nakajima et al., 2008 [115] |
| Antioxidants: Co Q-10 | Mouse | Lee et al. 2014 [116] |
| Antioxidants: Tempol | Rat | Yang et al., 2016 [100] |
| Essential Fatty Acids: ω-3 | Rat | Nguyen et al., 2007 [121] |
| Essential Fatty Acids: ω-3, Vit A | Rat | Schnebelen et al., 2009 [124] |
| Essential Fatty Acids: ω-3/ ω-6 | Rat | Huang et al., 2011 [125] |
| Natural compounds: epigallocatechin (green tea) | Rat | Osborne 2008 [128] |
| Natural compounds: gallocatechin and epigallocatechin (dark green tea) | Rat | Chu et al., 2010 [129] |
| Natural compounds: forskolin, homotaurine, L-carnosine | Rat | Russo et al., 2015 [130] |
| Natural compounds: intravitreal (AAPH) | Mouse | Yokohama et al., 2014 [131] |
| Natural compounds: Brimonidine | Rat | Lee et al., 2012 [132] |
| Natural compounds: TUDCA | Rat | Boatright et al., 2006 [113] |
| Natural compounds: Saffranal (saffron) and bear bile | Rat | Fernández-Sánchez et al., 2011 [134], 2005 [135] |
| Natural compounds: Ginkho Biloba | Rat | Eckert et al., 2005 [136] Cybulska-Heinrich et al, 2012 [137] |
| Antioxidant: Melatonin and 5-MCA-NAT | Mouse | Martínez-Águila et al., 2016 [118] |
| Antioxidant: Tempol | Mouse | Yang et al., 2016 [119] |
Abbreviations: Vit: vitamin; GSH: glutathione; Co Q-10: Coenzyme Q-10; ω-3 / ω-6: omega-3/omega-6 fatty acids; AAPH: 2,2'-azobis (2-amidinopropane) dihydrochloride; TUDCA: Taurousodeoxycholic acid; 5-MCA-NAT: 5-Methoxycarbonylamino-N-Acetyltryptamine.