Table 1.

ΔE_rev and derived P_I/P_Cl for cysteine mutants of LRRC8A/C channels

Mutants	ΔErev	PI/PCl	n
	mV
WT/WT	−5.90 ± 0.24	1.29 ± 0.01	5
T5C/WT	−7.13 ± 1.80	1.35 ± 0.10	4
E6C/E6C	−19.90 ± 1.04	2.29 ± 0.10	7
L7C/WT	−4.92 ± 0.85	1.23 ± 0.04	4
R8C/R8C	−9.10 ± 0.82	1.47 ± 0.05	3
Y9C/Q9C	−9.24 ± 0.40	1.48 ± 0.02	3
A11C/S11C	−7.2 ± 0.90	1.36 ± 0.05	3
D12C/E12C	−8.03 ± 0.53	1.41 ± 0.03	4
T13C/WT	−6.6 ± 1.20	1.30 ± 0.06	3
Q14C/Q14C	−4.92 ± 0.85	1.23 ± 0.04	4
P15C/P15C	−7.38 ± 0.57	1.37 ± 0.03	4