Table 3.

Direct binding of hit compounds to the NSD2 SET domain as measured by surface plasmon resonance, with SAH and SAM as positive controls

Compound name	kon	koff	Kd
	m−1 s−1	s−1	μm
SAH	2.33 × 103	1.19 × 10−2	5.1
SAM	4.06 × 103	1.70 × 10−2	4.2
DA03003-1	3.67 × 104	1.34 × 10−2	0.37
PF-03882845	8.55 × 103	3.31 × 10−2	3.9
Chaetocin	2.21 × 103	4.59 × 10−5	0.02
TC LPA5 4	4.29 × 103	3.59 × 10−2	8.4
ABT-199	4.39 × 103	3.64 × 10−2	8.3