Table 2.
KIF3AC and KIF3AB model parameter estimation
| Parameter | Estimate | Lower limit | Upper limit |
|---|---|---|---|
| KIF3AC | |||
| k1a (μm−1s−1) | 3.31 | 1.00a,b | 4.20 |
| k1c (μm−1s−1) | 3.29 | 2.40 | 5.70a,c |
| k2a (s−1) | 77.7 | ||
| k2c (s−1) | 7.6 | ||
| k3a (s−1) | 90.9 | 87.3 | 93.9 |
| k3c (s−1) | 13.0 | 10.1 | 16.6 |
| λ | 0.1069 | 0.1059 | 0.1083 |
| Training MSE | 1.45 × 10−4 | ||
| Validation MSE | 2.11 × 10−4 | ||
| KIF3AB | |||
| k1a (μm−1s−1) | 4.20 | 4.02 | 4.40 |
| k1b (μm−1s−1) | 4.20 | 4.02 | 4.40 |
| k2a (s−1) | 89.9 | ||
| k2b (s−1) | 80.2 | ||
| k3a (s−1) | 38.3 | 34.2 | 43.1 |
| k3b (s−1) | 38.3 | 34.2 | 43.1 |
| λ | 0.1104 | 0.1093 | 0.1115 |
| Training MSE | 1.09 × 10−4 | ||
| Validation MSE | 1.39 × 10−4 | ||
a Parameter was practically non-identifiable, and either a lower bound or upper bound could not be determined.
b KIF3A lower limit was set as the intrinsic KIF3C MT association rate.
c KIF3C upper limit was set as the intrinsic KIF3A MT association rate.