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. 2018 Aug 9;12(9):1540–1558. doi: 10.1002/1878-0261.12319

Figure 9.

Figure 9

An illustrative summary of the findings. Basal‐like BCCs, when exposed to S100A4 present in TME, increase secretion of numerous pro‐inflammatory cytokines (1). The secreted factors convert monocytes into TAMs (2), which stimulate EMT and promote aggressive functions (proliferation, chemoresistance, and motility) in BCCs (3).