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. 2018 Aug 1;8(9):1405–1411. doi: 10.1002/2211-5463.12493

Figure 3.

Figure 3

Inhibition of PDGFRβ and SRC in vitro by GS‐493, but not IIB‐08 and 11a‐1. Kinase activities of purified human PDGFRβ or human SRC in vitro were measured in the presence of serial dilutions of IIB‐08, 11a‐1, or GS‐493. Graphs show relative inhibition of kinase activity in the presence of indicated concentration of each inhibitor, setting the activity without SHP2 inhibitor as 0%. The bars indicate the range of technical duplicates, and the blue dots indicate the average of the two values obtained (n = 1). Data were fit to sigmoidal dose–response curves (green lines). No statistical analysis was performed. IC 50s for GS‐493 are found in the main text.