Table 2.
Pharmacokinetic parameters of the largest monomer ion pair (m/z 415.2) after oral administration of C. pilosula saponins to mice.
| Fro | Cp | Cs | Con | Mod | |
|---|---|---|---|---|---|
| Parameter | Oral administration (n = 3) | ||||
| Tmax (h) | 6 | 3 | 3 | 6 | 1 |
| Cmax (ppb) | 109 ± 22.9a | 98.5 ± 14.4b | 95.7 ± 10.1b | 88.3 ± 20.4b | 69.83 ± 10.7c |
| t1/2 (h) | 3.53 ± 0.33 | 4.94 ± 0.44 | 3.85 ± 0.62 | 3.49 ± 0.38 | 3.67 ± 0.5 |
| AUC0-t (ppb h) | 884.5 ± 65.5 | 615.55 ± 60 | 575.55 ± 78 | 695.45 ± 64.5 | 538.56 ± 49.9 |
| AUC0-t (ppb h) | 898.77 ± 65.9a | 788.43 ± 59.8b | 748.43 ± 63.3b | 761.74 ± 64.4b | 596.46 ± 50.5c |
| AUMC0-inf (ppb h2) | 5725.48 ± 535 | 6133.39 ± 478 | 5473.32 ± 298 | 6532.63 ± 567 | 3636.69 ± 357 |
| MRT0-inf (h) | 6.37 ± 1.5 | 7.79 ± 1 | 6.79 ± 0.8 | 8.58 ± 1.2 | 6.10 ± 0.8 |
| Vz/F (L/h kg) | 1.70 ± 0.25 | 2.13 ± 0.24 | 2.37 ± 0.18 | 1.46 ± 0.24 | 2.66 ± 0.37 |
| Cl/F (L/h kg) | 0.33 ± 0.06 | 0.38 ± 0.1 | 0.41 ± 0.07 | 0.39 ± 0.05 | 0.50 ± 0.14 |
a–c Data within a column without the same superscripts differ significantly (P < 0.05).
Fro = fructooligosaccharides group, Cp = Codonopsis pilosula polysaccharide group, Cs = Codonopsis pilosula saponins group, Con = control group, and Mod = DSS-induced colitis group.