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. Author manuscript; available in PMC: 2018 Dec 13.
Published in final edited form as: Nature. 2018 Jun 13;558(7710):401–405. doi: 10.1038/s41586-018-0211-2

Extended Data Figure 7. Sequence Conservation and Key Interaction Sites.

Extended Data Figure 7

(a) Multiple sequence alignment of the regions near and including the DRP1 residues mutated in this study: D190, D221 and G362, G363. The residue numbers apply to human DRP1, isoform 2 (UNIPROT identifier: O00429-3 which is also known as DLP1a).

(b) Sequence alignment of MID49 and MID51 at the region around residue R235 of MID49. R235 of MID49 corresponds to R243 of MID51.

(c) Sequence alignment of DRP1 Isoform 1 vs Isoform 2 showing the correspondence of S637 (Isoform 1) and S611 (Isoform 2).

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