Table 3.
Biochemical parameters obtained from the serum of Wistar ratstreated with a single dose of 40.5 mg/kg of EHA of Cissus sicyoides during the acute toxicity test. The values are expressed as mean ± S.E.M. (N = 6). Student's t-test/Mann-Whitney. * p ≤ 0.05. *Significant compared between treated and controls.
| Control | 40.5 mg/kg | |
|---|---|---|
| Males | ||
| Glucose (mg/dL) | 117.4 ± 2.8 | 117.0 ± 8.1 |
| Urea (mg/dL) | 45.2 ± 2.3 | 35.6 ± 2.3 |
| Serum creatinine (mg/dL) | 0.5 ± 0.1 | 0.6 ± 0.0 |
| Cholesterol (mg/dL) | 62.2 ± 2.4 | 62.4 ± 3.2 |
| Triglycerides (mg/dL) | 107.0 ± 16.6 | 137.6 ± 9.6 |
| Uric Acid (mg/dL) | 0.5 ± 0.2 | 1.6 ± 0.2* |
| AST (U/L) | 152.0 ± 6.5 | 171.6 ± 0.7 |
| ALT (U/L) | 60.9 ± 2.4 | 66.8 ± 7.11 |
| FAL (U/L) | 127.3 ± 3.2 | 149.2 ± 9.1 |
| CK (U/L) | 3732 ± 830.3 | 10284 ± 5198 |
| LDH (U/L) | 1353 ± 64.3 | 1363 ± 411.5 |
| Amylase (U/dL) | 758.7 ± 42.6 | 480.0 ± 14.1* |
| Protein (g/dL) | 6.10 ± 0.1 | 6.3 ± 0.1 |
| Albumin (g/dL) | 2.6 ± 0.1 | 2.6 ± 0.0 |
| Globulin (g/dL) | 3.9 ± 0.2 | 3.7 ± 0.1 |
| Females | ||
| Glucose (mg/dL) | 104.0 ± 2.2 | 109.3 ± 9.9 |
| Urea (mg/dL) | 40.2 ± 1.9 | 45.3 ± 2.5 |
| Serum creatinine (mg/dL) | 0.4 ± 0.0 | 0.6 ± 0.0 |
| Cholesterol (mg/dL) | 59.8 ± 2.2 | 61.5 ± 4.4 |
| Triglycerides (mg/dL) | 101.1 ± 8.9 | 108.0 ± 21.0 |
| Uric Acid (mg/dL) | 0.9 ± 0.1 | 1.7 ± 0.1* |
| AST (U/L) | 171.5 ± 24.8 | 208.5 ± 23.9* |
| ALT (U/L) | 53.8 ± 2.8 | 65.5 ± 6.2 |
| ALP (U/L) | 91.0 ± 13.5 | 123.8 ± 15.6 |
| CK (U/L) | 3547 ± 1037 | 17785 ± 8735 |
| LDH (U/L) | 1869 ± 278.1 | 975 ± 244.7 |
| Amylase (U/dL) | 670.7 ± 119.1 | 296.3 ± 7.4 |
| Protein (g/dL) | 6.51 ± 0.1 | 6.8 ± 0.1 |
| Albumin (g/dL) | 3.0 ± 0.1 | 2.87 ± 0.1 |
| Globulin (g/dL) | 4.23 ± 0.2 | 3.92 ± 0.1 |