Table 2.
Comparison of median values of ALRI, AST and lymphocytes as a function of toxicity
| Number of patients | ALRI median value (range) | p-values | AST median value (range) | p-values | Lymphocyte median value (range) | p-values | |
|---|---|---|---|---|---|---|---|
| Nausea | 0.623 | 0.970 | 0.733 | ||||
| G0 | 153 | 14.9 (1.3–172.3) | 21 (9–193) | 1.55 (0.43–10.40) | |||
| G1+G2 | 124 | 13.2 (3.2–141.0) | 21 (8–100) | 1.64 (0.58–10.51) | |||
| G3+G4 | 7 | 15.0 (9.3–28.6) | 24 (14–28) | 1.57 (0.98–2.07) | |||
| Vomiting | 0.852 | 0.929 | 0.687 | ||||
| G0 | 217 | 14.0 (2.1–172.3) | 21 (9–193) | 1.63 (0.43–5.85) | |||
| G1+G2 | 60 | 13.8 (1.4–82.6) | 20 (8–100) | 1.50 (0.87–10.51) | |||
| G3+G4 | 7 | 15.0 (9.2–29.7) | 24 (16–35) | 1.60 (0.82–2.07) | |||
| Diarrhea | 0.032 | 0.194 | 0.540 | ||||
| G0 | 150 | 14.9 (3.0–172.3) | 22 (9–193) | 1.57 (0.43–10.51) | |||
| G1+G2 | 117 | 13.9 (1.3–141.0) | 21 (10–88) | 1.57 (0.61–10.40) | |||
| G3+G4 | 17 | 11.4 (4.3–33.3) | 20 (8–43) | 1.93 (0.72–3.75) | |||
| Stomatitis | 0.230 | 0.073 | 0.468 | ||||
| G0 | 220 | 14.0 (1.3–172.3) | 20 (8–193) | 1.55 (0.43–10.51) | |||
| G1+G2 | 57 | 13.8 (4.8–102.3) | 23 (11–96) | 1.64 (0.77–4.75) | |||
| G3+G4 | 7 | 21.0 (12.6–31.0) | 30 (17–83) | 1.57 (1.25–2.68) | |||
| Fatigue | 0.010 | 0.0004 | 0.220 | ||||
| G0 | 159 | 13.2 (2.1–169.8) | 20 (8–117) | 1.54 (0.43–5.85) | |||
| G1+G2 | 106 | 14.4 (1.3–141.0) | 22 (9–142) | 1.64 (0.56–10.51) | |||
| G3+G4 | 19 | 20.1 (5.1–172.3) | 28 (11–193) | 1.46 (0.86–2.44) | |||
| Anemia | 0.221 | 0.187 | 0.857 | ||||
| G0 | 224 | 13.8 (1.3–172.3) | 21 (8–193) | 1.60 (0.43–10.51) | |||
| G1+G2 | 54 | 17.1 (3.5–102.3) | 23 (10–96) | 1.53 (0.72–3.75) | |||
| G3+G4 | 6 | 11.4 (4.2–55.4) | 16 (12–51) | 1.63 (0.92–2.87) | |||
| Neutropenia | 0.791 | 0.683 | 0.182 | ||||
| G0 | 101 | 14.8 (3.0–172.3) | 20 (9–193) | 1.51 (0.43–3.50) | |||
| G1+G2 | 58 | 12.5 (3.5–70.5) | 20 (10–117) | 1.67 (0.58–3.75) | |||
| G3+G4 | 124 | 14.7 (1.3–102.3) | 22 (8–100) | 1.57 (0.72–10.51) | |||
| Thrombocytopenia | 0.595 | 0.367 | 0.691 | ||||
| G0 | 219 | 14.1 (1.3–172.3) | 21 (8–193) | 1.60 (0.43–10.51) | |||
| G1+G2 | 59 | 13.2 (6.3–102.3) | 23 (12–88) | 1.60 (0.86–3.98) | |||
| G3+G4 | 6 | 19.3 (6.3–33.3) | 24 (17–33) | 1.47 (0.72–3.15) | |||
| Febrile neutropenia | 0.515 | 0.820 | 0.202 | ||||
| G0 | 278 | 14.1 (1.3–172.3) | 21 (8–193) | 1.57 (0.43–10.51) | |||
| G1+G2 | 2 | 10.3 (3.5–17.0) | 20 (10–30) | 2.32 (1.76–2.89) | |||
| G3+G4 | 4 | 11.5 (8.7–17.2) | 23 (18–28) | 1.90 (1.57–2.36) | |||
| Hemorrhage | 0.863 | 0.713 | 0.596 | ||||
| G0 | 249 | 13.9 (1.3–172.3) | 21 (8–193) | 1.57 (0.43–10.51) | |||
| G1+G2 | 35 | 15.6 (4.3–74.7) | 22 (9–142) | 1.68 (0.97–3.75) | |||
| G3+G4 | 0 | – | – | – | |||
| Hypertension | 0.096 | 0.429 | 0.077 | ||||
| G0 | 226 | 14.7 (1.3–172.3) | 21 (8–193) | 1.57 (0.43–10.40) | |||
| G1+G2 | 51 | 11.2 (2.0–82.6) | 20 (10–100) | 1.69 (0.77–10.51) | |||
| G3+G4 | 7 | 17.1 (6.4–102.3) | 25 (16–88) | 1.46 (0.86–2.97) | |||
| Thrombosis | 0.379 | 0.335 | 0.361 | ||||
| G0 | 232 | 14.1 (1.3–172.3) | 21 (8–193) | 1.57 (0.43–10.51) | |||
| G1+G2 | 19 | 14.6 (4.8–82.6) | 21 (12–100) | 1.31 (0.56–2.55) | |||
| G3+G4 | 33 | 11.9 (3.0–50.0) | 20 (9–73) | 1.73 (0.72–3.50) | |||
| Proteinuria | 0.001 | 0.005 | 0.514 | ||||
| G0 | 221 | 13.2 (1.4–169.8) | 20 (8–117) | 1.60 (0.43–10.51) | |||
| G1+G2 | 63 | 16.9 (4.2–172.3) | 25 (11–193) | 1.60 (0.61–3.50) | |||
| G3+G4 | 0 | – | – | – | |||
| Neurologic system | 0.028 | 0.168 | 0.044 | ||||
| G0 | 183 | 15.0 (1.3–172.3) | 22 (8–193) | 1.58 (0.43–10.40) | |||
| G1+G2 | 83 | 13.9 (3.2–102.3) | 20 (10–88) | 1.55 (0.58–10.51) | |||
| G3+G4 | 18 | 9.8 (3.5–50.0) | 18 (10.83) | 1.88 (1.17–4.75) |
Abbreviations: ALRI, aspartate aminotransferase-lymphocyte ratio index; AST, aspartate aminotransferase.