. 2018 Jun 22;19(8):572–577. doi: 10.1111/hiv.12626

Table 1.

Results by study participant for HIV‐1 RNA and dolutegravir (DTG) concentrations in plasma, cerebrospinal fluid and sperm, and total HIV‐1 DNA in peripheral blood mononuclear cells

		MONODO patient ID
		01	02	03	04	05	06	07	08
Plasma HIV‐1 RNA (copies/mL)	Baseline	< 20	< 20	< 20	< 20	< 20	< 20	< 20	< 20
	Week 4	< 20	< 20	< 20	< 20	< 20	< 20	< 20	< 20
	Week 8	< 20	< 20	< 20	< 20	< 20	< 20	< 20	< 20
	Week 12	< 20	< 20	< 20	< 20	< 20	< 20	< 20	< 20
	Week 16	< 20	< 20	< 20	< 20	< 20	< 20	< 20	NA^a
	Week 20	< 20	< 20	< 20	< 20	< 20	< 20	< 20	NA^a
	Week 24	< 20	< 20	< 20	< 20	< 20	< 20	< 20	NA^a
CSF HIV‐1 RNA (copies/mL)	Baseline	NA^b	< 20	NA^b	NA^b	NA^b	NA^b	NA^b	NA^b
CSF HIV‐1 RNA (copies/mL)	Week 24	< 20	< 20	< 20	28	< 20	NA	< 20	NA^a
Seminal fluid HIV‐1 RNA (copies/mL)^e	Baseline	< 40	NA^c	NA^c	< 40	< 40	< 40	NA^c	< 80
Seminal fluid HIV‐1 RNA (copies/mL)^e	Week 24	< 80	NA^c	NA^c	< 40	< 40	< 40	NA^c	NA^a
Total HIV‐1 DNA in PBMCs (DNA copies/10⁶ genomic equivalents)^f	Baseline	NA^d	170.9	NA^d	205.8	185.6	248.6	67.2	NA^d
	Week 24	NA^d	108.9	NA^d	279.1	72.0	483.3	145.5	NA^a
DTG concentration at week 24 (ng/mL)	Plasma	367	2088	1707	2104	2834	145	3100	NA^a
	CSF	9	10.4	6.1	5.4	10.4	NA	12.6	NA^a
	Seminal fluid	0	NA^c	NA^c	84	205	0	NA^c	NA^a

ID, identification; NA, not available; CSF, cerebrospinal fluid; PBMCs, peripheral blood mononuclear cells.

Patient discontinued the study at week 12.

Lumbar puncture optional at baseline.

Female or transgender: no sperm sample possible.

Missing data.

The limit of quantification in seminal fluid is 40 copies/mL because of sample dilution.

HIV‐1 DNA and the single‐copy host gene C‐C chemokine receptor type 5 (CCR5) were quantified by digital droplet polymerase chain reaction in parallel. Cell counts are displayed as genomic equivalents as defined by two CCR5 copies per genomic equivalent (cell).