Figure 2.

Variation frequency within the HBsAg ranging from a no substitution to 1 to 10 substitutions among acute and chronic strains. The data set for acute cases is a representative set of acute HBV in The Netherlands. The data set for chronic cases only represents those with risk behavior from various risk groups (<2010) and in most cases from MSM (>2010). The HBsAg amino acid sequence variation of the 6 genotypes was compared to the respective reference type 7. HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; MSM, men who have sex with men