Table 3.
Distribution of reverse transcriptase substitutions among strains isolated from HBV acute and chronic infected cases by genotype between 2004 and 2014 and substitutions associated with antiviral resistance (AVR)
| Acute | Chronic | |||
|---|---|---|---|---|
| Genotype | n substitutions/strains harboring variation in the RT | Substitution associated with AVR (n strains) a | n substitutions/strains harboring variation in the RT | Substitution associated with AVR (n strains) a |
| GtA | 197/168 | V173L (1) b , L180M (2) c , M204V (2) c | 137/79 | L180M (5) c , M204V (5) c |
| GtB | 19/16 | 74/47 | ||
| GtC | 19/10 | 54/25 | ||
| GtD | 162/108 | V173L (1) | 230/132 | |
| GtE | 35/25 | 105/36 | ||
| GtF | 12/8 | 4/2 | ||
| Total | 444/335 | 604/321 | ||
a
V173L, L180M, and M204V are associated with lamivudine, telbivudine, and entecavir resistance, respectively; L180M + M204V are associated with lamivudine and telbivudine resistance; V173L is associated with lamivudine resistance.
b
L180M/M204V/V173L was found as a triple substitution in 1 acute strain.
c
L180M/M204V was found as a double substitution in 1 acute strain and 5 chronic strains.
AVR, antiviral resistance; Gt, genotype; RT, reverse transcriptase.