Figure 3.

In Vivo Performance of the Edited Cells

(A) Human cell chimerism in the peripheral blood of NSG mice. (B) Human cell chimerism in the bone marrow of primary recipients 16 weeks after transplantation. (C) Multilineage in vivo differentiation of human unedited and edited cells in the mouse bone marrow. (D) Human erythroid (BFU-E) and non-erythroid (CFU-GM) colonies from engrafted cells 16 weeks after transplantation. (E) Indel percentage in the peripheral blood of the primary recipients at different time points 4–16 weeks after transplantation (n = 8 mice per group) and indel percentage of the input cells. (F) Indel percentage in different hematopoietic lineages 16 weeks after transplantation. The error bars represent the SEM of 8 mice. *p < 0.05 and **p < 0.001.