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. 2018 Sep;28(9):1309–1318. doi: 10.1101/gr.233809.117

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© 2018 Lu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Impact of de novo miRNAs on target gene expression. (A) mir-978 target repression. Target pools of the two mir-978 iso-miRs overlap. Targets in this overlapped pool are significantly up-regulated in the mir-978 KO line (P = 0.035, Kolmogorov–Smirnov test). (B) mir-983 target repression. Targets of mir-983 (miR-983-5p) are significantly up-regulated compared to nontargets in the mir-983 KO line (P < 0.001, Kolmogorov–Smirnov test). (C) mir-984 target repression. mir-984 (miR-984-5p), the youngest of the miRNAs, do not significantly down-regulate their targets (P > 0.05, Kolmogorov–Smirnov test). (D) Impact of de novo miRNAs on the testis transcriptome. Genes misregulated in miRNA KO lines are enriched for male-biased genes: χ² test (**) P < 0.01; (***) P < 0.001.