Figure 1. Aberrant Hippo signaling and downstream YAP/TAZ nuclear signaling are required for mammalian nonmelanoma skin cancers.

In normal tissue (left), skin cells temporarily express nuclear YAP/TAZ in order to expand cell population to maintain homeostasis or to facilitate wound healing. However, overactive Hippo signaling initiates basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (right) due to YAP/TAZ overexpression, nuclear localization, and their interaction with TEAD DNA‐binding transcription factors.