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. 2018 Jul 23;37(17):e98642. doi: 10.15252/embj.201798642

Figure 2. Yap deletion significantly reduces tumor burden in BCC mouse model.

Figure 2

  1. Scheme representing the genetic strategy used to induce BCC in mouse epidermis.
  2. Representative images of macroscopic tumor burden in mouse ears from Yap +/+ and Yap fl/fl at 8 and 25 weeks after tamoxifen.
  3. Kaplan–Meier survival curve comparing Yap +/+ with Yap fl/fl mice. The groups were compared using log‐rank (Mantel–Cox) test. *P < 0.0001.
  4. Representative histological analysis of ear BCC from Yap +/+ and Yap fl/fl. Scale bar is 100 μm.
  5. BCC histology comparing Yap fl/+ , Yap fl/fl , and Yap fl/S79A mutant backgrounds (YAPS79A does not bind TEAD transcription factors). Scale bar is 100 μm.
  6. YAP IHC in Yap fl/S79A background demonstrating YAP expression and nuclear localization. Scale bar is 50 μm.