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. 2018 Jul 23;37(17):e98642. doi: 10.15252/embj.201798642

Figure 5. Identification of YAP‐driven gene signature in BCC tumors.

Figure 5

  1. FACS methodology to purify ear BCC cells from Yap +/+ and Yap fl/fl mice (6 weeks after high‐dose tamoxifen administration) for RNAseq analysis.
  2. RNAseq heatmap of differentially expressed genes between Yap +/+ and Yap fl/fl BCC.
  3. Venn diagram of TEAD1/TEAD4 peaks found within differentially expressed genes from Yap‐null BCC.
  4. Ingenuity Pathway Analysis of differentially expressed genes between Yap +/+ and Yap fl/fl BCC.
  5. TEAD1, TEAD4, H3K27Ac, and input (control) peaks associated with known YAP targets (Cyr61 and AmotL2) or known AP1 targets (Egr1, Jun, Nupr1, Irs2) from BCC ChIPseq.