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. 2018 Jul 23;37(17):e98642. doi: 10.15252/embj.201798642

Figure EV5. YAP regulates JNK‐JUN pathway in allograft and in vitro model of BCC .

Figure EV5

  1. qPCR analysis of YAP and AP1 target genes in Dox‐inducible Yap knockout (TetON‐CRISPR‐YapKO) ASZ cells. Error bars represent SEM. Total of three biological replicates were used per condition.
  2. Representative macroscopic images of TetON‐CRISPR‐YapKO ASZ allograft BCC tumors (Control versus Dox treatment for 6 weeks).
  3. Tumor weight quantification of Control versus Dox‐treated TetON‐CRISPR‐YapKO ASZ allograft BCC tumors. Error bars represent SEM. The groups were compared using Student's t‐test. *P < 0.05; n = 3 per group.
  4. YAP IHC in TetON‐CRISPR‐YapKO ASZ allograft tumors from mice receiving Dox for 1 week versus 6 weeks. Blue arrows indicate Yap‐null clones. Scale bar is 100 μm.
  5. IHC analysis of YAP and JNK‐JUN pathway activity in Control (Yap‐wt) and Dox (Yap‐null)‐treated TetON‐CRISPR‐YapKO ASZ allograft BCC serial sections. Scale bar is 100 μm.