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. 2018 Jul 23;37(17):e98642. doi: 10.15252/embj.201798642

Figure 6. YAP regulates JNK‐JUN activity in BCC .

Figure 6

  1. qPCR validation of differentially expressed genes indicating that YAP affects AP1 (c‐JUN) target genes. Error bars represent SEM. Total of three biological replicates were used per genotype.
  2. Western blot analysis of JUN activity in Yap +/+ versus Yap fl/fl BCC at 9 weeks after high‐dose tamoxifen administration.
  3. IHC analysis of YAP and JNK‐JUN pathway activity in Yap fl/fl and Yap +/+ BCC serial sections. Red arrows indicate YAP‐positive clones; blue arrows indicate YAP‐negative clones. Scale bar is 100 μm.
  4. Western blot analysis of the JNK‐JUN activity in doxycycline (Dox)‐inducible Yap knockout (TetON‐CRISPR‐YapKO) in ASZ and BSZ cells.